Journal article
Investigating brain structural maturation in children and adolescents born very preterm using the brain age framework
C Kelly, G Ball, LG Matthews, JL Cheong, LW Doyle, TE Inder, DK Thompson, PJ Anderson
Neuroimage | Published : 2022
Abstract
Very preterm (VP) birth is associated with an increased risk for later neurodevelopmental and behavioural challenges. Although the neurobiological underpinnings of such challenges continue to be explored, previous studies have reported brain volume and morphology alterations in children and adolescents born VP compared with full-term (FT)-born controls. How these alterations relate to the trajectory of brain maturation, with potential implications for later brain ageing, remains unclear. In this longitudinal study, we investigate the relationship between VP birth and brain development during childhood and adolescence. We construct a normative ‘brain age’ model to predict age over childhood a..
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Grants
Awarded by National Institute of Mental Health
Funding Acknowledgements
We thank members of the VIBeS and Developmental Imaging teams at the Murdoch Children's Research Institute, the Royal Children's Hos-pital Medical Imaging staff for their assistance and expertise in the col-lection of the MRI data included in this study, and the children and fam-ilies who participated. This research was supported by the Australian National Health and Medical Research Council [NHMRC; Project Grants 237117 , 491209 and 1066555 ; Centre of Clinical Research Excellence 546519 ; Centre of Research Excellence 1060733 and 1153176 ; Investi-gator Grant 1176077 to PA and 1194497 to GB; Career Development Fel-lowship 1085754 to DT and 1141354 to JC] , an Australian Government Research Training Program (RTP) Scholarship and Monash Graduate Ex-cellence Scholarship to CK, Brigham and Women's Hospital Program for Interdisciplinary Neuroscience Award to LGM, the Murdoch Children's Research Institute, the Royal Children's Hospital, the Royal Children's Hospital Foundation, the Department of Paediatrics at the University of Melbourne, and the Victorian Government's Operational Infrastructure Support Program. Portions of this research were conducted on the O2 High Performance Compute Cluster, supported by the Research Com-puting Group, at Harvard Medical School.